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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
07/06/2022 |
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Actualizado : |
30/11/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
MACHADO, M.; CASTRO, M.B.; WILSON, T. M.; GONÇALVES , A. A. B.; PORTIANSKY, E.; RIET-CORREA, F.; BARROS, S. S. |
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Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MÁRCIO B. CASTRO, University of Brasilia, Brasília, Brazil; TAIS M. WILSON, University of Brasilia, Brasília, Brazil; ALEXANDRA A. B. GONÇALVES, University of Brasilia, Brasília, Brazil; ENRIQUE L. PORTIANSKY, National University of La Plata, La Plata, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Federal University of Bahia, Salvador, Brazil; SEVERO S. BARROS, Federal University of Santa Maria, Rio Grande do Sul, Brazil. |
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Título : |
Poisoning by Nierembergia veitchii: Effects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Veterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430 |
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ISSN : |
0300-9858 |
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DOI : |
10.1177/03009858221098430 |
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Idioma : |
Inglés |
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Notas : |
Article history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay. |
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Contenido : |
ABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022. MenosABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It ... Presentar Todo |
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Palabras claves : |
Arterial mineralization; Arteries; Enzootic calcinosis; Exosomes; Pathogenesis; PLATAFORMA DE SALUD ANIMAL; Toxicity; Vascular smooth muscle cells. |
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Asunto categoría : |
L50 Fisiología y bioquímica animal |
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Marc : |
LEADER 03391nam a2200313 a 4500
001 1063233
005 2022-11-30
008 2022 bl uuuu u01u1 u #d
022 $a0300-9858
024 7 $a10.1177/03009858221098430$2DOI
100 1 $aMACHADO, M.
245 $aPoisoning by Nierembergia veitchii$bEffects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis.$h[electronic resource]
260 $aVeterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430$c1177
500 $aArticle history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay.
520 $aABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022.
653 $aArterial mineralization
653 $aArteries
653 $aEnzootic calcinosis
653 $aExosomes
653 $aPathogenesis
653 $aPLATAFORMA DE SALUD ANIMAL
653 $aToxicity
653 $aVascular smooth muscle cells
700 1 $aCASTRO, M.B.
700 1 $aWILSON, T. M.
700 1 $aGONÇALVES , A. A. B.
700 1 $aPORTIANSKY, E.
700 1 $aRIET-CORREA, F.
700 1 $aBARROS, S. S.
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
27/07/2022 |
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Actualizado : |
27/02/2023 |
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Tipo de producción científica : |
Trabajos en Congresos/Conferencias |
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Autor : |
NAVAJAS, E.; RAVAGNOLO, O.; DE BARBIERI, I.; PRAVIA, M.I.; AGUILAR, I.; LEMA, O.M.; VERA, B.; PERAZA, P.; MARQUES, C. B.; VELAZCO, J.I.; CIAPPESONI, G. |
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Afiliación : |
ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; OLGA RAVAGNOLO GUMILA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; LUIS IGNACIO DE BARBIERI ETCHEBERRY, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARIA ISABEL PRAVIA NIN, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; OSCAR MARIO LEMA QUEIJO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; BRENDA VERA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PABLO PERAZA DOS SANTOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CAMILA BALCONI MARQUES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JOSÉ IGNACIO VELAZCO DE LOS REYES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Genetic selection of feed efficiency and methane emissions in sheep and cattle in Uruguay: progress and limitations. [29] |
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Complemento del título : |
Part 5 - Novel traits: environment and greenhouse gas- |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
In: Proceedings of the World Congress on Genetics Applied to Livestock Production (WCGALP), 12., Rotterdam, the Netherlands, 3-8 July 2022. doi: https://doi.org/10.3920/978-90-8686-940-4_29 |
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Páginas : |
164-167. |
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DOI : |
10.3920/978-90-8686-940-4_29 |
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Idioma : |
Inglés |
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Notas : |
Article history: Published online: February 9, 2023. -- Corresponding author: E.A. Navajas, email: enavajas@inia.org.uy -- Acknowledgements: The authors acknowledge the funding organizations INIA, Agencia Nacional de Investigación e Innovación (RTS_1_2012_1_3489), the European Union?s Horizon 2020 research and innovation program under grant agreement No 772787 (SMARTER) and the SusAn, ICT-AGRI 2 and FACCE ERA-GAS funding bodies (GrassToGas project). |
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Contenido : |
ABSTRACT.- Residual feed intake (RFI) and methane (CH4) emissions are potential new selection objectives in beef and sheep breeding programmes to assist reaching greenhouse gas mitigation targets and to support economic, social, and environmental sustainability. Phenotyping platforms in both species are in place in Uruguay, linked with the genetically evaluated populations of main breeds (Hereford, Merino, Corriedale, Dohne and Texel), being the basis of the reference populations for genomic selection. Current progress and main findings are described here. New selection indexes and selection criteria, as residual CH4, are needed given the potential unfavourable associations between CH4 and performance. Larger reference populations imply higher genomic prediction accuracies, accurate estimations of genetic correlations among feed intake, RFI, CH4 and performance and a comprehensive understanding of these associations. On-going rumen metagenomics and metatrascriptomics will also provide information about its value as predictor of genetic merit of these traits. |
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Palabras claves : |
Beef breeding programmes; Greenhouse gas (GHG) mitigation; Methane (CH4) emissions; Sheep breeding programmes. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16995/1/978-90-8686-940-4-29.pdf
https://www.wageningenacademic.com/doi/epdf/10.3920/978-90-8686-940-4_29
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Marc : |
LEADER 02623nam a2200313 a 4500
001 1063460
005 2023-02-27
008 2022 bl uuuu u01u1 u #d
024 7 $a10.3920/978-90-8686-940-4_29$2DOI
100 1 $aNAVAJAS, E.
245 $aGenetic selection of feed efficiency and methane emissions in sheep and cattle in Uruguay$bprogress and limitations. [29]$h[electronic resource]
260 $aIn: Proceedings of the World Congress on Genetics Applied to Livestock Production (WCGALP), 12., Rotterdam, the Netherlands, 3-8 July 2022. doi: https://doi.org/10.3920/978-90-8686-940-4_29$c8686
300 $a164-167.
500 $aArticle history: Published online: February 9, 2023. -- Corresponding author: E.A. Navajas, email: enavajas@inia.org.uy -- Acknowledgements: The authors acknowledge the funding organizations INIA, Agencia Nacional de Investigación e Innovación (RTS_1_2012_1_3489), the European Union?s Horizon 2020 research and innovation program under grant agreement No 772787 (SMARTER) and the SusAn, ICT-AGRI 2 and FACCE ERA-GAS funding bodies (GrassToGas project).
520 $aABSTRACT.- Residual feed intake (RFI) and methane (CH4) emissions are potential new selection objectives in beef and sheep breeding programmes to assist reaching greenhouse gas mitigation targets and to support economic, social, and environmental sustainability. Phenotyping platforms in both species are in place in Uruguay, linked with the genetically evaluated populations of main breeds (Hereford, Merino, Corriedale, Dohne and Texel), being the basis of the reference populations for genomic selection. Current progress and main findings are described here. New selection indexes and selection criteria, as residual CH4, are needed given the potential unfavourable associations between CH4 and performance. Larger reference populations imply higher genomic prediction accuracies, accurate estimations of genetic correlations among feed intake, RFI, CH4 and performance and a comprehensive understanding of these associations. On-going rumen metagenomics and metatrascriptomics will also provide information about its value as predictor of genetic merit of these traits.
653 $aBeef breeding programmes
653 $aGreenhouse gas (GHG) mitigation
653 $aMethane (CH4) emissions
653 $aSheep breeding programmes
700 1 $aRAVAGNOLO, O.
700 1 $aDE BARBIERI, I.
700 1 $aPRAVIA, M.I.
700 1 $aAGUILAR, I.
700 1 $aLEMA, O.M.
700 1 $aVERA, B.
700 1 $aPERAZA, P.
700 1 $aMARQUES, C. B.
700 1 $aVELAZCO, J.I.
700 1 $aCIAPPESONI, G.
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